MOCKSLATE

Has an NFL game ever ended 45–21?

Yes. 45–21 has been an NFL final score 28 times, most recently Lions 45, Cardinals 21 on October 11, 2026. It first happened on September 28, 1947, the 352nd different final score the league had produced.

Every NFL game that ended 45–21

Datenewest firstWinner45 pointsLoser21 pointsWherehome teamRoundplayoffsWindowstandalone game
Oct 11, 2026Detroit LionsArizona CardinalsCardinals——
Dec 21, 2025Cincinnati BengalsMiami DolphinsDolphins——
Nov 13, 2017Carolina PanthersMiami DolphinsPanthers—Monday Night Football
Nov 30, 2014Houston TexansTennessee TitansTexans——
Nov 10, 2014Philadelphia EaglesCarolina PanthersEagles—Monday Night Football
Oct 27, 2013Denver BroncosWashington CommandersBroncos——
Nov 26, 2006Indianapolis ColtsPhiladelphia EaglesColts—Sunday Night Football
Sep 4, 1994Indianapolis ColtsTennessee TitansColts——
Nov 14, 1993San Francisco 49ersTampa Bay BuccaneersBuccaneers——
Oct 2, 1988Cincinnati BengalsLas Vegas RaidersRaiders——
Dec 17, 1972Denver BroncosNew England PatriotsBroncos——
Oct 8, 1972New York GiantsNew Orleans SaintsGiants——
Nov 22, 1970Dallas CowboysWashington CommandersCommanders——
Oct 17, 1965San Francisco 49ersLos Angeles RamsRams——
Nov 29, 1964Green Bay PackersDallas CowboysCowboys——
Dec 2, 1962Dallas CowboysCleveland BrownsCowboys——
Nov 5, 1961Indianapolis ColtsGreen Bay PackersColts——
Dec 6, 1959Detroit LionsArizona CardinalsLions——
Dec 7, 1952Detroit LionsChicago BearsLions——
Dec 9, 1951Chicago BearsNYYNYY——
Nov 11, 1951Los Angeles RamsArizona CardinalsRams——
Dec 10, 1950Cleveland BrownsWashington CommandersCommanders——
Dec 3, 1950Detroit LionsBCLBCL——
Nov 20, 1949Detroit LionsNew York GiantsGiants——
Dec 12, 1948Philadelphia EaglesDetroit LionsEagles——
Dec 7, 1947Arizona CardinalsPhiladelphia EaglesEagles——
Nov 23, 1947Washington CommandersArizona CardinalsCommanders——
Sep 28, 1947Arizona CardinalsDetroit LionsCardinals——

Scores next to 45–21

Where 45–21 sits

45–21 was the 352nd different final score in NFL history, and it first happened in 1947. The league has produced 1,097 different final scores through 18,340 games. See the whole grid →

About the data

Scorigami is a term coined by Jon Bois in 2014; his 2016 video explains the idea. Game data from nflverse and the FiveThirtyEight NFL archive: every NFL and AFL regular-season and playoff game since 1920, Super Bowls included, the AAFC and the Pro Bowl left out. Franchises carry their current name, so the Baltimore Colts count for Indianapolis and the Houston Oilers for Tennessee.

Updated: October 26, 2026