San Francisco 49ers vs. Tennessee Titans on Thursday Night Football
The San Francisco 49ers are 0-1 against the Tennessee Titans in regular-season Thursday Night Football games since 2021. The teams have met once on Thursday night in that span, with San Francisco winning 0 and Tennessee winning 1.
49ers vs. Titans Thursday Night Football record: 0-1
0-1 from the 49ers’ side, 1-0 from the Titans' side. Most recent: Dec 23, 2021, Titans 20, 49ers 17 at Nissan Stadium. Regular season only; ties count as ties.
Every San Francisco 49ers vs. Tennessee Titans Thursday Night Football game
Newest first. The running record is the 49ers’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | 49ersresult · running record |
|---|---|---|---|---|
| Dec 23, 2021 | 49ers at Titans | Titans 20, 49ers 17 | Nissan Stadium | L · 0-1 |
San Francisco 49ers vs. Tennessee Titans Thursday Night Football FAQ
- When did the 49ers and Titans last meet on Thursday Night Football?
- Dec 23, 2021: Titans 20, 49ers 17 at Nissan Stadium.
- What is the 49ers' all-time Thursday Night Football record against the Titans?
- 0-1 in 1 game since 2021, from the 49ers' side.
- When did the 49ers last beat the Titans on Thursday Night Football?
- Never in these games: the 49ers are 0-1 here.
- When did the Titans last beat the 49ers on Thursday Night Football?
- Dec 23, 2021: Titans 20, 49ers 17 at Nissan Stadium.
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Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025