Indianapolis Colts vs San Francisco 49ers on Monday Night Football
The Indianapolis Colts are 0-1 on Monday night against the San Francisco 49ers since 2025: 1 game, 0 won, 1 lost.
Indianapolis Colts vs San Francisco 49ers Monday night record since 2025
0-1 from the Colts’ side, 1-0 from the 49ers' side. Most recent: Dec 22, 2025, 49ers 48, Colts 27 at Lucas Oil Stadium. Regular season only; ties count as ties.
Every Colts–49ers Monday night game
Newest first. The running record is the Colts’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Coltsresult · running record |
|---|---|---|---|---|
| Dec 22, 2025 | 49ers at Colts | 49ers 48, Colts 27 | Lucas Oil Stadium | L · 0-1 |
Indianapolis Colts vs San Francisco 49ers Monday night FAQ
- When did the Indianapolis Colts and San Francisco 49ers last meet on Monday night?
- Dec 22, 2025: San Francisco 49ers 48, Indianapolis Colts 27 at Lucas Oil Stadium.
- What is the Indianapolis Colts' all-time Monday night record against the San Francisco 49ers?
- 0-1 in 1 game since 2025, from the Indianapolis Colts' side.
- When did the Indianapolis Colts last beat the San Francisco 49ers on Monday night?
- Never in these games: the Indianapolis Colts are 0-1 here.
- When did the San Francisco 49ers last beat the Indianapolis Colts on Monday night?
- Dec 22, 2025: San Francisco 49ers 48, Indianapolis Colts 27 at Lucas Oil Stadium.
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Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025