Indianapolis Colts vs. San Francisco 49ers on Monday Night Football
The Indianapolis Colts are 0-1 against the San Francisco 49ers in regular-season Monday Night Football games since 2025. The teams have met once on Monday night in that span, with Indianapolis winning 0 and San Francisco winning 1.
Colts vs. 49ers Monday Night Football record: 0-1
0-1 from the Colts’ side, 1-0 from the 49ers' side. Most recent: Dec 22, 2025, 49ers 48, Colts 27 at Lucas Oil Stadium. Regular season only; ties count as ties.
Every Indianapolis Colts vs. San Francisco 49ers Monday Night Football game
Newest first. The running record is the Colts’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Coltsresult · running record |
|---|---|---|---|---|
| Dec 22, 2025 | 49ers at Colts | 49ers 48, Colts 27 | Lucas Oil Stadium | L · 0-1 |
Indianapolis Colts vs. San Francisco 49ers Monday Night Football FAQ
- When did the Colts and 49ers last meet on Monday Night Football?
- Dec 22, 2025: 49ers 48, Colts 27 at Lucas Oil Stadium.
- What is the Colts' all-time Monday Night Football record against the 49ers?
- 0-1 in 1 game since 2025, from the Colts' side.
- When did the Colts last beat the 49ers on Monday Night Football?
- Never in these games: the Colts are 0-1 here.
- When did the 49ers last beat the Colts on Monday Night Football?
- Dec 22, 2025: 49ers 48, Colts 27 at Lucas Oil Stadium.
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Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025