Indianapolis Colts vs. San Francisco 49ers in Primetime and Holiday Windows

Colts vs. 49ers primetime and holiday record: 1-1

1-1 from the Colts’ side, 1-1 from the 49ers' side. Most recent: Dec 22, 2025, 49ers 48, Colts 27 at Lucas Oil Stadium. Regular season only; ties count as ties.

Every Indianapolis Colts vs. San Francisco 49ers primetime and holiday game

Newest first. The running record is the Colts’ record in these games through that date. Stadiums are listed from 2000 onward.

Schedulegami status

The Colts and 49ers have never played on Thursday night. They have also never met on Thanksgiving, on Christmas, on a Saturday, in the Kickoff Game, in an international game, on a Friday, or on a Wednesday. A game in an open window would be a schedulegami, a first meeting there, whichever team hosts.

• The only Colts–49ers Sunday night game was in San Francisco, never in Indianapolis.
• The only Colts–49ers Monday night game was in Indianapolis, never in San Francisco.

Every open Colts matchup window · every open 49ers matchup window

Indianapolis Colts vs. San Francisco 49ers primetime and holiday FAQ

When did the Colts and 49ers last meet in a primetime or holiday window?

Dec 22, 2025: 49ers 48, Colts 27 at Lucas Oil Stadium.

What is the Colts' all-time primetime and holiday record against the 49ers?

1-1 in 2 games since 2021, from the Colts' side.

When did the Colts last beat the 49ers in a primetime or holiday window?

Oct 24, 2021: Colts 30, 49ers 18 at Levi's Stadium.

When did the 49ers last beat the Colts in a primetime or holiday window?

Dec 22, 2025: 49ers 48, Colts 27 at Lucas Oil Stadium.