Indianapolis Colts vs San Francisco 49ers in Primetime and Holiday Windows
The Indianapolis Colts are 1-1 in primetime and holiday windows against the San Francisco 49ers since 2021: 2 games, 1 won, 1 lost.
Indianapolis Colts vs San Francisco 49ers primetime and holiday record since 2021
1-1 from the Colts’ side, 1-1 from the 49ers' side. Most recent: Dec 22, 2025, 49ers 48, Colts 27 at Lucas Oil Stadium. Regular season only; ties count as ties.
Every Colts–49ers primetime and holiday game
Newest first. The running record is the Colts’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Coltsresult · running record |
|---|---|---|---|---|
| Dec 22, 2025 | 49ers at Colts | 49ers 48, Colts 27 | Lucas Oil Stadium | L · 1-1 |
| Oct 24, 2021 | Colts at 49ers | Colts 30, 49ers 18 | Levi's Stadium | W · 1-0 |
Indianapolis Colts vs San Francisco 49ers primetime and holiday FAQ
- When did the Indianapolis Colts and San Francisco 49ers last meet in a primetime or holiday window?
- Dec 22, 2025: San Francisco 49ers 48, Indianapolis Colts 27 at Lucas Oil Stadium.
- What is the Indianapolis Colts' all-time primetime or holiday record against the San Francisco 49ers?
- 1-1 in 2 games since 2021, from the Indianapolis Colts' side.
- When did the Indianapolis Colts last beat the San Francisco 49ers in a primetime or holiday window?
- Oct 24, 2021: Indianapolis Colts 30, San Francisco 49ers 18 at Levi's Stadium.
- When did the San Francisco 49ers last beat the Indianapolis Colts in a primetime or holiday window?
- Dec 22, 2025: San Francisco 49ers 48, Indianapolis Colts 27 at Lucas Oil Stadium.
More: every Colts primetime and holiday game · every 49ers primetime and holiday game · Colts 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025