Detroit Lions vs. San Francisco 49ers on Thanksgiving
The Detroit Lions are 0-1 against the San Francisco 49ers in regular-season Thanksgiving games since 1966. The teams have met once on Thanksgiving in that span, with Detroit winning 0 and San Francisco winning 1.
Lions vs. 49ers Thanksgiving record: 0-1
0-1 from the Lions’ side, 1-0 from the 49ers' side. Most recent: Nov 24, 1966, 49ers 41, Lions 14. Regular season only; ties count as ties.
Every Detroit Lions vs. San Francisco 49ers Thanksgiving game
Newest first. The running record is the Lions’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Lionsresult · running record |
|---|---|---|---|---|
| Nov 24, 1966 | 49ers at Lions | 49ers 41, Lions 14 | — | L · 0-1 |
Detroit Lions vs. San Francisco 49ers Thanksgiving FAQ
- When did the Lions and 49ers last meet on Thanksgiving?
- Nov 24, 1966: 49ers 41, Lions 14.
- What is the Lions' all-time Thanksgiving record against the 49ers?
- 0-1 in 1 game since 1966, from the Lions' side.
- When did the Lions last beat the 49ers on Thanksgiving?
- Never in these games: the Lions are 0-1 here.
- When did the 49ers last beat the Lions on Thanksgiving?
- Nov 24, 1966: 49ers 41, Lions 14.
More: every Lions primetime and holiday game · every 49ers primetime and holiday game · Lions 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025