Detroit Lions vs San Francisco 49ers on Thanksgiving
The Detroit Lions are 0-1 on Thanksgiving against the San Francisco 49ers since 1966: 1 game, 0 won, 1 lost.
Detroit Lions vs San Francisco 49ers Thanksgiving record since 1966
0-1 from the Lions’ side, 1-0 from the 49ers' side. Most recent: Nov 24, 1966, 49ers 41, Lions 14. Regular season only; ties count as ties.
Every Lions–49ers Thanksgiving game
Newest first. The running record is the Lions’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Lionsresult · running record |
|---|---|---|---|---|
| Nov 24, 1966 | 49ers at Lions | 49ers 41, Lions 14 | — | L · 0-1 |
Detroit Lions vs San Francisco 49ers Thanksgiving FAQ
- When did the Detroit Lions and San Francisco 49ers last meet on Thanksgiving?
- Nov 24, 1966: San Francisco 49ers 41, Detroit Lions 14.
- What is the Detroit Lions' all-time Thanksgiving record against the San Francisco 49ers?
- 0-1 in 1 game since 1966, from the Detroit Lions' side.
- When did the Detroit Lions last beat the San Francisco 49ers on Thanksgiving?
- Never in these games: the Detroit Lions are 0-1 here.
- When did the San Francisco 49ers last beat the Detroit Lions on Thanksgiving?
- Nov 24, 1966: San Francisco 49ers 41, Detroit Lions 14.
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Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025