Carolina Panthers vs. San Francisco 49ers on Monday Night Football
The Carolina Panthers are 0-2 against the San Francisco 49ers in regular-season Monday Night Football games since 1997. The teams have met twice on Monday night in that span, with Carolina winning 0 and San Francisco winning 2.
Panthers vs. 49ers Monday Night Football record: 0-2
0-2 from the Panthers’ side, 2-0 from the 49ers' side. Most recent: Nov 24, 2025, 49ers 20, Panthers 9 at Levi's Stadium. Regular season only; ties count as ties.
Every Carolina Panthers vs. San Francisco 49ers Monday Night Football game
Newest first. The running record is the Panthers’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Panthersresult · running record |
|---|---|---|---|---|
| Nov 24, 2025 | Panthers at 49ers | 49ers 20, Panthers 9 | Levi's Stadium | L · 0-2 |
| Sep 29, 1997 | 49ers at Panthers | 49ers 34, Panthers 21 | — | L · 0-1 |
Carolina Panthers vs. San Francisco 49ers Monday Night Football FAQ
- When did the Panthers and 49ers last meet on Monday Night Football?
- Nov 24, 2025: 49ers 20, Panthers 9 at Levi's Stadium.
- What is the Panthers' all-time Monday Night Football record against the 49ers?
- 0-2 in 2 games since 1997, from the Panthers' side.
- When did the Panthers last beat the 49ers on Monday Night Football?
- Never in these games: the Panthers are 0-2 here.
- When did the 49ers last beat the Panthers on Monday Night Football?
- Nov 24, 2025: 49ers 20, Panthers 9 at Levi's Stadium.
- What is the 49ers' longest Monday Night Football winning streak against the Panthers?
- 2 games, from the 1997 season through the 2025 season.
More: every Panthers primetime and holiday game · every 49ers primetime and holiday game · Panthers 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025