Carolina Panthers vs San Francisco 49ers on Monday Night Football
The Carolina Panthers are 0-2 on Monday night against the San Francisco 49ers since 1997: 2 games, 0 won, 2 lost.
Carolina Panthers vs San Francisco 49ers Monday night record since 1997
0-2 from the Panthers’ side, 2-0 from the 49ers' side. Most recent: Nov 24, 2025, 49ers 20, Panthers 9 at Levi's Stadium. Regular season only; ties count as ties.
Every Panthers–49ers Monday night game
Newest first. The running record is the Panthers’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Panthersresult · running record |
|---|---|---|---|---|
| Nov 24, 2025 | Panthers at 49ers | 49ers 20, Panthers 9 | Levi's Stadium | L · 0-2 |
| Sep 29, 1997 | 49ers at Panthers | 49ers 34, Panthers 21 | — | L · 0-1 |
Carolina Panthers vs San Francisco 49ers Monday night FAQ
- When did the Carolina Panthers and San Francisco 49ers last meet on Monday night?
- Nov 24, 2025: San Francisco 49ers 20, Carolina Panthers 9 at Levi's Stadium.
- What is the Carolina Panthers' all-time Monday night record against the San Francisco 49ers?
- 0-2 in 2 games since 1997, from the Carolina Panthers' side.
- When did the Carolina Panthers last beat the San Francisco 49ers on Monday night?
- Never in these games: the Carolina Panthers are 0-2 here.
- When did the San Francisco 49ers last beat the Carolina Panthers on Monday night?
- Nov 24, 2025: San Francisco 49ers 20, Carolina Panthers 9 at Levi's Stadium.
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Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025