Carolina Panthers vs. San Francisco 49ers in Primetime and Holiday Windows
The Carolina Panthers are 1-3 against the San Francisco 49ers in regular-season primetime and holiday games since 1997. The teams have met 4 times in primetime and holiday windows in that span, with Carolina winning 1 and San Francisco winning 3.
Panthers vs. 49ers primetime and holiday record: 1-3
1-3 from the Panthers’ side, 3-1 from the 49ers' side. Most recent: Nov 24, 2025, 49ers 20, Panthers 9 at Levi's Stadium. Regular season only; ties count as ties.
Every Carolina Panthers vs. San Francisco 49ers primetime and holiday game
Newest first. The running record is the Panthers’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Windowtwo when they overlap | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Panthersresult · running record |
|---|---|---|---|---|---|
| Nov 24, 2025 | Monday Night Football | Panthers at 49ers | 49ers 20, Panthers 9 | Levi's Stadium | L · 1-3 |
| Oct 7, 2001 | Sunday Night Football | Panthers at 49ers | 49ers 24, Panthers 14 | 3Com Park | L · 1-2 |
| Dec 18, 1999 | Saturday | 49ers at Panthers | Panthers 41, 49ers 24 | — | W · 1-1 |
| Sep 29, 1997 | Monday Night Football | 49ers at Panthers | 49ers 34, Panthers 21 | — | L · 0-1 |
Schedulegami status
The Panthers and 49ers have never played on Thursday night. They have also never met on Thanksgiving, on Christmas, in the Kickoff Game, in an international game, on a Friday, or on a Wednesday. A game in an open window would be a schedulegami, a first meeting there, whichever team hosts.
- The only Panthers–49ers Saturday game was in Carolina, never in San Francisco.
- The only Panthers–49ers Sunday night game was in San Francisco, never in Carolina.
Every open Panthers matchup window · every open 49ers matchup window
Carolina Panthers vs. San Francisco 49ers primetime and holiday FAQ
- When did the Panthers and 49ers last meet in a primetime or holiday window?
- Nov 24, 2025: 49ers 20, Panthers 9 at Levi's Stadium.
- What is the Panthers' all-time primetime and holiday record against the 49ers?
- 1-3 in 4 games since 1997, from the Panthers' side.
- When did the Panthers last beat the 49ers in a primetime or holiday window?
- Dec 18, 1999: Panthers 41, 49ers 24.
- When did the 49ers last beat the Panthers in a primetime or holiday window?
- Nov 24, 2025: 49ers 20, Panthers 9 at Levi's Stadium.
- What is the 49ers' longest primetime and holiday winning streak against the Panthers?
- 2 games, from the 2001 season through the 2025 season.
More: every Panthers primetime and holiday game · every 49ers primetime and holiday game · Panthers 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025