Carolina Panthers vs San Francisco 49ers in Primetime and Holiday Windows
The Carolina Panthers are 1-3 in primetime and holiday windows against the San Francisco 49ers since 1997: 4 games, 1 won, 3 lost.
Carolina Panthers vs San Francisco 49ers primetime and holiday record since 1997
1-3 from the Panthers’ side, 3-1 from the 49ers' side. Most recent: Nov 24, 2025, 49ers 20, Panthers 9 at Levi's Stadium. Regular season only; ties count as ties.
Every Panthers–49ers primetime and holiday game
Newest first. The running record is the Panthers’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Panthersresult · running record |
|---|---|---|---|---|
| Nov 24, 2025 | Panthers at 49ers | 49ers 20, Panthers 9 | Levi's Stadium | L · 1-3 |
| Oct 7, 2001 | Panthers at 49ers | 49ers 24, Panthers 14 | 3Com Park | L · 1-2 |
| Dec 18, 1999 | 49ers at Panthers | Panthers 41, 49ers 24 | — | W · 1-1 |
| Sep 29, 1997 | 49ers at Panthers | 49ers 34, Panthers 21 | — | L · 0-1 |
Carolina Panthers vs San Francisco 49ers primetime and holiday FAQ
- When did the Carolina Panthers and San Francisco 49ers last meet in a primetime or holiday window?
- Nov 24, 2025: San Francisco 49ers 20, Carolina Panthers 9 at Levi's Stadium.
- What is the Carolina Panthers' all-time primetime or holiday record against the San Francisco 49ers?
- 1-3 in 4 games since 1997, from the Carolina Panthers' side.
- When did the Carolina Panthers last beat the San Francisco 49ers in a primetime or holiday window?
- Dec 18, 1999: Carolina Panthers 41, San Francisco 49ers 24.
- When did the San Francisco 49ers last beat the Carolina Panthers in a primetime or holiday window?
- Nov 24, 2025: San Francisco 49ers 20, Carolina Panthers 9 at Levi's Stadium.
More: every Panthers primetime and holiday game · every 49ers primetime and holiday game · Panthers 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025