Buffalo Bills vs San Francisco 49ers on Sunday Night Football
The Buffalo Bills are 1-2 on Sunday night against the San Francisco 49ers since 1995: 3 games, 1 won, 2 lost.
Buffalo Bills vs San Francisco 49ers Sunday night record since 1995
1-2 from the Bills’ side, 2-1 from the 49ers' side. Most recent: Dec 1, 2024, Bills 35, 49ers 10 at New Era Field. Regular season only; ties count as ties.
Every Bills–49ers Sunday night game
Newest first. The running record is the Bills’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Billsresult · running record |
|---|---|---|---|---|
| Dec 1, 2024 | 49ers at Bills | Bills 35, 49ers 10 | New Era Field | W · 1-2 |
| Dec 2, 2001 | Bills at 49ers | 49ers 35, Bills 0 | 3Com Park | L · 0-2 |
| Dec 3, 1995 | Bills at 49ers | 49ers 27, Bills 17 | — | L · 0-1 |
Buffalo Bills vs San Francisco 49ers Sunday night FAQ
- When did the Buffalo Bills and San Francisco 49ers last meet on Sunday night?
- Dec 1, 2024: Buffalo Bills 35, San Francisco 49ers 10 at New Era Field.
- What is the Buffalo Bills' all-time Sunday night record against the San Francisco 49ers?
- 1-2 in 3 games since 1995, from the Buffalo Bills' side.
- When did the Buffalo Bills last beat the San Francisco 49ers on Sunday night?
- Dec 1, 2024: Buffalo Bills 35, San Francisco 49ers 10 at New Era Field.
- When did the San Francisco 49ers last beat the Buffalo Bills on Sunday night?
- Dec 2, 2001: San Francisco 49ers 35, Buffalo Bills 0 at 3Com Park.
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Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025