Buffalo Bills vs. San Francisco 49ers on Sunday Night Football
The Buffalo Bills are 1-2 against the San Francisco 49ers in regular-season Sunday Night Football games since 1995. The teams have met 3 times on Sunday night in that span, with Buffalo winning 1 and San Francisco winning 2.
Bills vs. 49ers Sunday Night Football record: 1-2
1-2 from the Bills’ side, 2-1 from the 49ers' side. Most recent: Dec 1, 2024, Bills 35, 49ers 10 at New Era Field. Regular season only; ties count as ties.
Every Buffalo Bills vs. San Francisco 49ers Sunday Night Football game
Newest first. The running record is the Bills’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Billsresult · running record |
|---|---|---|---|---|
| Dec 1, 2024 | 49ers at Bills | Bills 35, 49ers 10 | New Era Field | W · 1-2 |
| Dec 2, 2001 | Bills at 49ers | 49ers 35, Bills 0 | 3Com Park | L · 0-2 |
| Dec 3, 1995 | Bills at 49ers | 49ers 27, Bills 17 | — | L · 0-1 |
Buffalo Bills vs. San Francisco 49ers Sunday Night Football FAQ
- When did the Bills and 49ers last meet on Sunday Night Football?
- Dec 1, 2024: Bills 35, 49ers 10 at New Era Field.
- What is the Bills' all-time Sunday Night Football record against the 49ers?
- 1-2 in 3 games since 1995, from the Bills' side.
- When did the Bills last beat the 49ers on Sunday Night Football?
- Dec 1, 2024: Bills 35, 49ers 10 at New Era Field.
- When did the 49ers last beat the Bills on Sunday Night Football?
- Dec 2, 2001: 49ers 35, Bills 0 at 3Com Park.
- What is the 49ers' longest Sunday Night Football winning streak against the Bills?
- 2 games, from the 1995 season through the 2001 season.
More: every Bills primetime and holiday game · every 49ers primetime and holiday game · Bills 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025