Buffalo Bills vs San Francisco 49ers on Monday Night Football
The Buffalo Bills are 1-0 on Monday night against the San Francisco 49ers since 2020: 1 game, 1 won, 0 lost.
Buffalo Bills vs San Francisco 49ers Monday night record since 2020
1-0 from the Bills’ side, 0-1 from the 49ers' side. Most recent: Dec 7, 2020, Bills 34, 49ers 24 at State Farm Stadium. Regular season only; ties count as ties.
Every Bills–49ers Monday night game
Newest first. The running record is the Bills’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Billsresult · running record |
|---|---|---|---|---|
| Dec 7, 2020 | Bills at 49ers | Bills 34, 49ers 24 | State Farm Stadium | W · 1-0 |
Buffalo Bills vs San Francisco 49ers Monday night FAQ
- When did the Buffalo Bills and San Francisco 49ers last meet on Monday night?
- Dec 7, 2020: Buffalo Bills 34, San Francisco 49ers 24 at State Farm Stadium.
- What is the Buffalo Bills' all-time Monday night record against the San Francisco 49ers?
- 1-0 in 1 game since 2020, from the Buffalo Bills' side.
- When did the Buffalo Bills last beat the San Francisco 49ers on Monday night?
- Dec 7, 2020: Buffalo Bills 34, San Francisco 49ers 24 at State Farm Stadium.
- When did the San Francisco 49ers last beat the Buffalo Bills on Monday night?
- Never in these games: the San Francisco 49ers are 0-1 here.
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Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025