Buffalo Bills vs. San Francisco 49ers on Monday Night Football
The Buffalo Bills are 1-0 against the San Francisco 49ers in regular-season Monday Night Football games since 2020. The teams have met once on Monday night in that span, with Buffalo winning 1 and San Francisco winning 0.
Bills vs. 49ers Monday Night Football record: 1-0
1-0 from the Bills’ side, 0-1 from the 49ers' side. Most recent: Dec 7, 2020, Bills 34, 49ers 24 at State Farm Stadium. Regular season only; ties count as ties.
Every Buffalo Bills vs. San Francisco 49ers Monday Night Football game
Newest first. The running record is the Bills’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Billsresult · running record |
|---|---|---|---|---|
| Dec 7, 2020 | Bills at 49ers | Bills 34, 49ers 24 | State Farm Stadium | W · 1-0 |
Buffalo Bills vs. San Francisco 49ers Monday Night Football FAQ
- When did the Bills and 49ers last meet on Monday Night Football?
- Dec 7, 2020: Bills 34, 49ers 24 at State Farm Stadium.
- What is the Bills' all-time Monday Night Football record against the 49ers?
- 1-0 in 1 game since 2020, from the Bills' side.
- When did the Bills last beat the 49ers on Monday Night Football?
- Dec 7, 2020: Bills 34, 49ers 24 at State Farm Stadium.
- When did the 49ers last beat the Bills on Monday Night Football?
- Never in these games: the 49ers are 0-1 here.
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Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025