Buffalo Bills vs San Francisco 49ers in Primetime and Holiday Windows
The Buffalo Bills are 2-2 in primetime and holiday windows against the San Francisco 49ers since 1995: 4 games, 2 won, 2 lost.
Buffalo Bills vs San Francisco 49ers primetime and holiday record since 1995
2-2 from the Bills’ side, 2-2 from the 49ers' side. Most recent: Dec 1, 2024, Bills 35, 49ers 10 at New Era Field. Regular season only; ties count as ties.
Every Bills–49ers primetime and holiday game
Newest first. The running record is the Bills’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Billsresult · running record |
|---|---|---|---|---|
| Dec 1, 2024 | 49ers at Bills | Bills 35, 49ers 10 | New Era Field | W · 2-2 |
| Dec 7, 2020 | Bills at 49ers | Bills 34, 49ers 24 | State Farm Stadium | W · 1-2 |
| Dec 2, 2001 | Bills at 49ers | 49ers 35, Bills 0 | 3Com Park | L · 0-2 |
| Dec 3, 1995 | Bills at 49ers | 49ers 27, Bills 17 | — | L · 0-1 |
Buffalo Bills vs San Francisco 49ers primetime and holiday FAQ
- When did the Buffalo Bills and San Francisco 49ers last meet in a primetime or holiday window?
- Dec 1, 2024: Buffalo Bills 35, San Francisco 49ers 10 at New Era Field.
- What is the Buffalo Bills' all-time primetime or holiday record against the San Francisco 49ers?
- 2-2 in 4 games since 1995, from the Buffalo Bills' side.
- When did the Buffalo Bills last beat the San Francisco 49ers in a primetime or holiday window?
- Dec 1, 2024: Buffalo Bills 35, San Francisco 49ers 10 at New Era Field.
- When did the San Francisco 49ers last beat the Buffalo Bills in a primetime or holiday window?
- Dec 2, 2001: San Francisco 49ers 35, Buffalo Bills 0 at 3Com Park.
More: every Bills primetime and holiday game · every 49ers primetime and holiday game · Bills 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025