Buffalo Bills vs. San Francisco 49ers in Primetime and Holiday Windows
The Buffalo Bills are 2-2 against the San Francisco 49ers in regular-season primetime and holiday games since 1995. The teams have met 4 times in primetime and holiday windows in that span, with Buffalo winning 2 and San Francisco winning 2.
Bills vs. 49ers primetime and holiday record: 2-2
2-2 from the Bills’ side, 2-2 from the 49ers' side. Most recent: Dec 1, 2024, Bills 35, 49ers 10 at New Era Field. Regular season only; ties count as ties.
Every Buffalo Bills vs. San Francisco 49ers primetime and holiday game
Newest first. The running record is the Bills’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Windowtwo when they overlap | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Billsresult · running record |
|---|---|---|---|---|---|
| Dec 1, 2024 | Sunday Night Football | 49ers at Bills | Bills 35, 49ers 10 | New Era Field | W · 2-2 |
| Dec 7, 2020 | Monday Night Football | Bills at 49ers | Bills 34, 49ers 24 | State Farm Stadium | W · 1-2 |
| Dec 2, 2001 | Sunday Night Football | Bills at 49ers | 49ers 35, Bills 0 | 3Com Park | L · 0-2 |
| Dec 3, 1995 | Sunday Night Football | Bills at 49ers | 49ers 27, Bills 17 | — | L · 0-1 |
Schedulegami status
The Bills and 49ers have never played on Thursday night. They have also never met on Thanksgiving, on Christmas, on a Saturday, in the Kickoff Game, in an international game, on a Friday, or on a Wednesday. A game in an open window would be a schedulegami, a first meeting there, whichever team hosts.
- The only Bills–49ers Monday night game was in San Francisco, never in Buffalo.
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Buffalo Bills vs. San Francisco 49ers primetime and holiday FAQ
- When did the Bills and 49ers last meet in a primetime or holiday window?
- Dec 1, 2024: Bills 35, 49ers 10 at New Era Field.
- What is the Bills' all-time primetime and holiday record against the 49ers?
- 2-2 in 4 games since 1995, from the Bills' side.
- When did the Bills last beat the 49ers in a primetime or holiday window?
- Dec 1, 2024: Bills 35, 49ers 10 at New Era Field.
- When did the 49ers last beat the Bills in a primetime or holiday window?
- Dec 2, 2001: 49ers 35, Bills 0 at 3Com Park.
- What is the Bills' longest primetime and holiday winning streak against the 49ers?
- 2 games, from the 2020 season through the 2024 season.
- What is the 49ers' longest primetime and holiday winning streak against the Bills?
- 2 games, from the 1995 season through the 2001 season.
More: every Bills primetime and holiday game · every 49ers primetime and holiday game · Bills 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025