Arizona Cardinals vs San Francisco 49ers on Monday Night Football
The Arizona Cardinals are 1-6 on Monday night against the San Francisco 49ers since 1999: 7 games, 1 won, 6 lost.
Arizona Cardinals vs San Francisco 49ers Monday night record since 1999
1-6 from the Cardinals’ side, 6-1 from the 49ers' side. Most recent: Nov 21, 2022, 49ers 38, Cardinals 10 at Azteca Stadium. Regular season only; ties count as ties.
Every Cardinals–49ers Monday night game
Newest first. The running record is the Cardinals’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Cardinalsresult · running record |
|---|---|---|---|---|
| Nov 21, 2022 | 49ers at Cardinals | 49ers 38, Cardinals 10 | Azteca Stadium | L · 1-6 |
| Oct 29, 2012 | 49ers at Cardinals | 49ers 24, Cardinals 3 | University of Phoenix Stadium | L · 1-5 |
| Nov 29, 2010 | 49ers at Cardinals | 49ers 27, Cardinals 6 | University of Phoenix Stadium | L · 1-4 |
| Dec 14, 2009 | Cardinals at 49ers | 49ers 24, Cardinals 9 | Candlestick Park | L · 1-3 |
| Nov 10, 2008 | 49ers at Cardinals | Cardinals 29, 49ers 24 | University of Phoenix Stadium | W · 1-2 |
| Sep 10, 2007 | Cardinals at 49ers | 49ers 20, Cardinals 17 | Monster Park | L · 0-2 |
| Sep 27, 1999 | 49ers at Cardinals | 49ers 24, Cardinals 10 | — | L · 0-1 |
Arizona Cardinals vs San Francisco 49ers Monday night FAQ
- When did the Arizona Cardinals and San Francisco 49ers last meet on Monday night?
- Nov 21, 2022: San Francisco 49ers 38, Arizona Cardinals 10 at Azteca Stadium.
- What is the Arizona Cardinals' all-time Monday night record against the San Francisco 49ers?
- 1-6 in 7 games since 1999, from the Arizona Cardinals' side.
- When did the Arizona Cardinals last beat the San Francisco 49ers on Monday night?
- Nov 10, 2008: Arizona Cardinals 29, San Francisco 49ers 24 at University of Phoenix Stadium.
- When did the San Francisco 49ers last beat the Arizona Cardinals on Monday night?
- Nov 21, 2022: San Francisco 49ers 38, Arizona Cardinals 10 at Azteca Stadium.
More: every Cardinals primetime and holiday game · every 49ers primetime and holiday game · Cardinals 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025