Arizona Cardinals vs. San Francisco 49ers on Monday Night Football
The Arizona Cardinals are 1-6 against the San Francisco 49ers in regular-season Monday Night Football games since 1999. The teams have met 7 times on Monday night in that span, with Arizona winning 1 and San Francisco winning 6.
Cardinals vs. 49ers Monday Night Football record: 1-6
1-6 from the Cardinals’ side, 6-1 from the 49ers' side. Most recent: Nov 21, 2022, 49ers 38, Cardinals 10 at Azteca Stadium. Regular season only; ties count as ties.
Every Arizona Cardinals vs. San Francisco 49ers Monday Night Football game
Newest first. The running record is the Cardinals’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Cardinalsresult · running record |
|---|---|---|---|---|
| Nov 21, 2022 | 49ers at Cardinals | 49ers 38, Cardinals 10 | Azteca Stadium | L · 1-6 |
| Oct 29, 2012 | 49ers at Cardinals | 49ers 24, Cardinals 3 | University of Phoenix Stadium | L · 1-5 |
| Nov 29, 2010 | 49ers at Cardinals | 49ers 27, Cardinals 6 | University of Phoenix Stadium | L · 1-4 |
| Dec 14, 2009 | Cardinals at 49ers | 49ers 24, Cardinals 9 | Candlestick Park | L · 1-3 |
| Nov 10, 2008 | 49ers at Cardinals | Cardinals 29, 49ers 24 | University of Phoenix Stadium | W · 1-2 |
| Sep 10, 2007 | Cardinals at 49ers | 49ers 20, Cardinals 17 | Monster Park | L · 0-2 |
| Sep 27, 1999 | 49ers at Cardinals | 49ers 24, Cardinals 10 | — | L · 0-1 |
Arizona Cardinals vs. San Francisco 49ers Monday Night Football FAQ
- When did the Cardinals and 49ers last meet on Monday Night Football?
- Nov 21, 2022: 49ers 38, Cardinals 10 at Azteca Stadium.
- What is the Cardinals' all-time Monday Night Football record against the 49ers?
- 1-6 in 7 games since 1999, from the Cardinals' side.
- When did the Cardinals last beat the 49ers on Monday Night Football?
- Nov 10, 2008: Cardinals 29, 49ers 24 at University of Phoenix Stadium.
- When did the 49ers last beat the Cardinals on Monday Night Football?
- Nov 21, 2022: 49ers 38, Cardinals 10 at Azteca Stadium.
- What is the 49ers' longest Monday Night Football winning streak against the Cardinals?
- 4 games, from the 2009 season through the 2022 season.
More: every Cardinals primetime and holiday game · every 49ers primetime and holiday game · Cardinals 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025