Arizona Cardinals vs San Francisco 49ers in Primetime and Holiday Windows
The Arizona Cardinals are 3-9 in primetime and holiday windows against the San Francisco 49ers since 1999: 12 games, 3 won, 9 lost.
Arizona Cardinals vs San Francisco 49ers primetime and holiday record since 1999
3-9 from the Cardinals’ side, 9-3 from the 49ers' side. Most recent: Nov 21, 2022, 49ers 38, Cardinals 10 at Azteca Stadium. Regular season only; ties count as ties.
Every Cardinals–49ers primetime and holiday game
Newest first. The running record is the Cardinals’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Cardinalsresult · running record |
|---|---|---|---|---|
| Nov 21, 2022 | 49ers at Cardinals | 49ers 38, Cardinals 10 | Azteca Stadium | L · 3-9 |
| Dec 26, 2020 | 49ers at Cardinals | 49ers 20, Cardinals 12 | State Farm Stadium | L · 3-8 |
| Oct 31, 2019 | 49ers at Cardinals | 49ers 28, Cardinals 25 | State Farm Stadium | L · 3-7 |
| Oct 6, 2016 | Cardinals at 49ers | Cardinals 33, 49ers 21 | Levi's Stadium | W · 3-6 |
| Oct 29, 2012 | 49ers at Cardinals | 49ers 24, Cardinals 3 | University of Phoenix Stadium | L · 2-6 |
| Nov 29, 2010 | 49ers at Cardinals | 49ers 27, Cardinals 6 | University of Phoenix Stadium | L · 2-5 |
| Dec 14, 2009 | Cardinals at 49ers | 49ers 24, Cardinals 9 | Candlestick Park | L · 2-4 |
| Nov 10, 2008 | 49ers at Cardinals | Cardinals 29, 49ers 24 | University of Phoenix Stadium | W · 2-3 |
| Sep 10, 2007 | Cardinals at 49ers | 49ers 20, Cardinals 17 | Monster Park | L · 1-3 |
| Oct 2, 2005 | 49ers at Cardinals | Cardinals 31, 49ers 14 | Azteca Stadium | W · 1-2 |
| Dec 21, 2002 | 49ers at Cardinals | 49ers 17, Cardinals 14 | Sun Devil Stadium | L · 0-2 |
| Sep 27, 1999 | 49ers at Cardinals | 49ers 24, Cardinals 10 | — | L · 0-1 |
Arizona Cardinals vs San Francisco 49ers primetime and holiday games by decade
| Decadeby season | Gamesin this window | Cardinals recordW-L-T |
|---|---|---|
| 1990s | 1 | 0-1 |
| 2000s | 5 | 2-3 |
| 2010s | 4 | 1-3 |
| 2020s | 2 | 0-2 |
Arizona Cardinals vs San Francisco 49ers primetime and holiday FAQ
- When did the Arizona Cardinals and San Francisco 49ers last meet in a primetime or holiday window?
- Nov 21, 2022: San Francisco 49ers 38, Arizona Cardinals 10 at Azteca Stadium.
- What is the Arizona Cardinals' all-time primetime or holiday record against the San Francisco 49ers?
- 3-9 in 12 games since 1999, from the Arizona Cardinals' side.
- When did the Arizona Cardinals last beat the San Francisco 49ers in a primetime or holiday window?
- Oct 6, 2016: Arizona Cardinals 33, San Francisco 49ers 21 at Levi's Stadium.
- When did the San Francisco 49ers last beat the Arizona Cardinals in a primetime or holiday window?
- Nov 21, 2022: San Francisco 49ers 38, Arizona Cardinals 10 at Azteca Stadium.
More: every Cardinals primetime and holiday game · every 49ers primetime and holiday game · Cardinals 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025