Arizona Cardinals vs. San Francisco 49ers in Primetime and Holiday Windows
The Arizona Cardinals are 3-9 against the San Francisco 49ers in regular-season primetime and holiday games since 1999. The teams have met 12 times in primetime and holiday windows in that span, with Arizona winning 3 and San Francisco winning 9.
Cardinals vs. 49ers primetime and holiday record: 3-9
3-9 from the Cardinals’ side, 9-3 from the 49ers' side. Most recent: Nov 21, 2022, 49ers 38, Cardinals 10 at Azteca Stadium. Regular season only; ties count as ties.
Every Arizona Cardinals vs. San Francisco 49ers primetime and holiday game
Newest first. The running record is the Cardinals’ record in these games through that date. Stadiums are listed from 2000 onward.
| Dateregular season | Windowtwo when they overlap | Matchupaway at home | Scorewinner first | Stadiumfrom 2000 | Cardinalsresult · running record |
|---|---|---|---|---|---|
| Nov 21, 2022 | Monday Night Football · International | 49ers at Cardinals | 49ers 38, Cardinals 10 | Azteca Stadium | L · 3-9 |
| Dec 26, 2020 | Saturday | 49ers at Cardinals | 49ers 20, Cardinals 12 | State Farm Stadium | L · 3-8 |
| Oct 31, 2019 | Thursday Night Football | 49ers at Cardinals | 49ers 28, Cardinals 25 | State Farm Stadium | L · 3-7 |
| Oct 6, 2016 | Thursday Night Football | Cardinals at 49ers | Cardinals 33, 49ers 21 | Levi's Stadium | W · 3-6 |
| Oct 29, 2012 | Monday Night Football | 49ers at Cardinals | 49ers 24, Cardinals 3 | University of Phoenix Stadium | L · 2-6 |
| Nov 29, 2010 | Monday Night Football | 49ers at Cardinals | 49ers 27, Cardinals 6 | University of Phoenix Stadium | L · 2-5 |
| Dec 14, 2009 | Monday Night Football | Cardinals at 49ers | 49ers 24, Cardinals 9 | Candlestick Park | L · 2-4 |
| Nov 10, 2008 | Monday Night Football | 49ers at Cardinals | Cardinals 29, 49ers 24 | University of Phoenix Stadium | W · 2-3 |
| Sep 10, 2007 | Monday Night Football | Cardinals at 49ers | 49ers 20, Cardinals 17 | Monster Park | L · 1-3 |
| Oct 2, 2005 | International | 49ers at Cardinals | Cardinals 31, 49ers 14 | Azteca Stadium | W · 1-2 |
| Dec 21, 2002 | Saturday | 49ers at Cardinals | 49ers 17, Cardinals 14 | Sun Devil Stadium | L · 0-2 |
| Sep 27, 1999 | Monday Night Football | 49ers at Cardinals | 49ers 24, Cardinals 10 | — | L · 0-1 |
Arizona Cardinals vs. San Francisco 49ers primetime and holiday games by decade
| Decadeby season | Gamesin this window | Cardinals recordW-L-T |
|---|---|---|
| 1990s | 1 | 0-1 |
| 2000s | 5 | 2-3 |
| 2010s | 4 | 1-3 |
| 2020s | 2 | 0-2 |
Schedulegami status
The Cardinals and 49ers have never met on Thanksgiving, on Christmas, in the Kickoff Game, on a Friday, or on a Wednesday. A game in an open window would be a schedulegami, a first meeting there, whichever team hosts.
- All 2 Cardinals–49ers Saturday games have been in Arizona, never in San Francisco.
- The only Cardinals–49ers Sunday night game was in Mexico City, never in San Francisco.
Every open Cardinals matchup window · every open 49ers matchup window
Arizona Cardinals vs. San Francisco 49ers primetime and holiday FAQ
- When did the Cardinals and 49ers last meet in a primetime or holiday window?
- Nov 21, 2022: 49ers 38, Cardinals 10 at Azteca Stadium.
- What is the Cardinals' all-time primetime and holiday record against the 49ers?
- 3-9 in 12 games since 1999, from the Cardinals' side.
- When did the Cardinals last beat the 49ers in a primetime or holiday window?
- Oct 6, 2016: Cardinals 33, 49ers 21 at Levi's Stadium.
- When did the 49ers last beat the Cardinals in a primetime or holiday window?
- Nov 21, 2022: 49ers 38, Cardinals 10 at Azteca Stadium.
- What is the 49ers' longest primetime and holiday winning streak against the Cardinals?
- 3 games, from the 2009 season through the 2012 season.
More: every Cardinals primetime and holiday game · every 49ers primetime and holiday game · Cardinals 2026 schedule tools · look up another pairing
Updated: September 7, 2026 · 13,814 regular-season games in the file, 1966 to 2025