Has an NFL game ever ended 45–16?
Yes. 45–16 has been an NFL final score 3 times, most recently Bills 45, 49ers 16 on October 16, 2016. It first happened on October 28, 1960, the 523rd different final score the league had produced.
Every NFL game that ended 45–16
| Datenewest first | Winner45 points | Loser16 points | Wherehome team | Roundplayoffs | Windowstandalone game |
|---|---|---|---|---|---|
| Oct 16, 2016 | Buffalo Bills | San Francisco 49ers | Bills | — | — |
| Dec 26, 2011 | New Orleans Saints | Atlanta Falcons | Saints | — | Monday Night Football |
| Oct 28, 1960 | Los Angeles Chargers | New England Patriots | Patriots | — | — |
Scores next to 45–16
Where 45–16 sits
45–16 was the 523rd different final score in NFL history, and it first happened in 1960. The league has produced 1,097 different final scores through 18,340 games. See the whole grid →
About the data
Scorigami is a term coined by Jon Bois in 2014; his 2016 video explains the idea. Game data from nflverse and the FiveThirtyEight NFL archive: every NFL and AFL regular-season and playoff game since 1920, Super Bowls included, the AAFC and the Pro Bowl left out. Franchises carry their current name, so the Baltimore Colts count for Indianapolis and the Houston Oilers for Tennessee.
Updated: October 26, 2026